A qualitative study of the contribution of pharmacists to heart failure management in Scotland

Study objectives: (1) To identify the medication management needs of chronic heart failure (CHF) patients and their caregivers; (2) To examine the perceived support for medication management available to these people from health professionals; (3) To identify the actual and potential perceived contribution of pharmacists to medication management. Setting: A mixed urban/ rural region in the west of Scotland. Design: Semi-structured qualitative research interviews. Participants: A total of 50 people with CHF (NYHA Class II and III) due to left ventricular systolic dysfunction (33 males; mean age 67 years, 17 females; mean age 68 years) and 30 nominated caregivers recruited from the outpatient departments of two hospitals in the West of Scotland. Sampling was purposive to include patients from a range of CHF severity, ages and sexes. Main results: Managing medications was a responsibility shared by both the patients with CHF and caregivers. Treatment regimens were reported to be difficult to comply with. Health professionals were seen to provide little support for medication management. Pharmacists were viewed as being a good and accessible source of practical assistance who were also knowledgeable about the individual’s heart health history. Participants reported valuing advice from pharmacists about the side effects of medications and for their assistance in reducing the complex logistics of medication management and in having medications delivered. Conclusions: Patients with CHF and caregivers voiced a willingness to try to manage their medication regimen accurately but had a limited capacity to do so. Pharmacists were viewed as providing valuable support to patients with CHF and their caregivers, in terms of medication management. The extended role of pharmacists in medication management of CHF should be encouraged

Randomised controlled trial of specialist nurse intervention in heart failure

<p>Objectives. To determine whether specialist nurse intervention improves outcome in patients with chronic heart failure.</p> <p>Design. Randomised controlled trial.</p> <p>Setting. Acute medical admissions unit in a teaching hospital.</p> <p>Participants. 165 patients admitted with heart failure due to left ventricular systolic dysfunction. The intervention started before discharge and continued thereafter with home visits for up to 1 year.</p> <p>Main outcome measures. Time to first event analysis of death from all causes or readmission to hospital with worsening heart failure.</p> <p>Results. 31 patients (37%) in the intervention group died or were readmitted with heart failure compared with 45 (53%) in the usual care group (hazard ratio=0.61, 95% confidence interval 0.33 to 0.96).Compared with usual care, patients in the intervention group had fewer readmissions for any reason (86 v 114, P=0.018), fewer admissions for heart failure (19 v 45, P<0.001) and spent fewer days in hospital for heart failure (mean 3.43 v 7.46 days, P=0.0051).</p> <p>Conclusions. Specially trained nurses can improve the outcome of patients admitted to hospital with heart failure.</p&gt

The Toric Phases of the Y^{p,q} Quivers

We construct all connected toric phases of the recently discovered $Y^{p,q}$ quivers and show their IR equivalence using Seiberg duality. We also compute the R and global U(1) charges for a generic toric phase of $Y^{p,q}$.Comment: 14 pages, 3 figure

"Holey Sheets" - Pfaffians and Subdeterminants as D-brane Operators in Large N Gauge Theories

In the AdS/CFT correspondence, wrapped D3-branes (such as "giant gravitons") on the string theory side of the correspondence have been identified with Pfaffian, determinant and subdeterminant operators on the field theory side. We substantiate this identification by showing that the presence of pairs of such operators in a correlation function of a large N gauge theory naturally leads to a modified 't Hooft expansion including also worldsheets with boundaries. This happens independently of supersymmetry or conformal invariance.Comment: 39 pages, 10 figures, harvma

Exceptional Collections and del Pezzo Gauge Theories

Stacks of D3-branes placed at the tip of a cone over a del Pezzo surface provide a way of geometrically engineering a small but rich class of gauge/gravity dualities. We develop tools for understanding the resulting quiver gauge theories using exceptional collections. We prove two important results for a general quiver gauge theory: 1) we show the ordering of the nodes can be determined up to cyclic permutation and 2) we derive a simple formula for the ranks of the gauge groups (at the conformal point) in terms of the numbers of bifundamentals. We also provide a detailed analysis of four node quivers, examining when precisely mutations of the exceptional collection are related to Seiberg duality.Comment: 26 pages, 1 figure; v2 footnote 2 amended; v3 ref adde

Dibaryon Spectroscopy

The AdS/CFT correspondence relates dibaryons in superconformal gauge theories to holomorphic curves in Kaehler-Einstein surfaces. The degree of the holomorphic curves is proportional to the gauge theory conformal dimension of the dibaryons. Moreover, the number of holomorphic curves should match, in an appropriately defined sense, the number of dibaryons. Using AdS/CFT backgrounds built from the generalized conifolds of Gubser, Shatashvili, and Nekrasov (1999), we show that the gauge theory prediction for the dimension of dibaryonic operators does indeed match the degree of the corresponding holomorphic curves. For AdS/CFT backgrounds built from cones over del Pezzo surfaces, we are able to match the degree of the curves to the conformal dimension of dibaryons for the n'th del Pezzo surface, n=1,2,...,6. Also, for the del Pezzos and the A_k type generalized conifolds, for the dibaryons of smallest conformal dimension, we are able to match the number of holomorphic curves with the number of possible dibaryon operators from gauge theory.Comment: 30 pages, 6 figures, corrected refs; v3 typos correcte

New results on superconformal quivers

All superconformal quivers are shown to satisfy the relation c = a and are thus good candidates for being the field theory living on D3 branes probing CY singularities. We systematically study 3 block and 4 block chiral quivers which admit a superconformal fixed point of the RG equation. Most of these theories are known to arise as living on D3 branes at a singular CY manifold, namely complex cones over del Pezzo surfaces. In the process we find a procedure of getting a new superconformal quiver from a known one. This procedure is termed "shrinking" and, in the 3 block case, leads to the discovery of two new models. Thus, the number of superconformal 3 block quivers is 16 rather than the previously known 14. We prove that this list exausts all the possibilities. We suggest that all rank 2 chiral quivers are either del Pezzo quivers or can be obtained by shrinking a del Pezzo quiver and verify this statement for all 4 block quivers, where a lot of "shrunk'' del Pezzo models exist.Comment: 51 pages, many figure

Exceptional collections and D-branes probing toric singularities

We demonstrate that a strongly exceptional collection on a singular toric surface can be used to derive the gauge theory on a stack of D3-branes probing the Calabi-Yau singularity caused by the surface shrinking to zero size. A strongly exceptional collection, i.e., an ordered set of sheaves satisfying special mapping properties, gives a convenient basis of D-branes. We find such collections and analyze the gauge theories for weighted projective spaces, and many of the Y^{p,q} and L^{p,q,r} spaces. In particular, we prove the strong exceptionality for all p in the Y^{p,p-1} case, and similarly for the Y^{p,p-2r} case.Comment: 49 pages, 6 figures; v2 refs added; v3 published versio

Dibaryons from Exceptional Collections

We discuss aspects of the dictionary between brane configurations in del Pezzo geometries and dibaryons in the dual superconformal quiver gauge theories. The basis of fractional branes defining the quiver theory at the singularity has a K-theoretic dual exceptional collection of bundles which can be used to read off the spectrum of dibaryons in the weakly curved dual geometry. Our prescription identifies the R-charge R and all baryonic U(1) charges Q_I with divisors in the del Pezzo surface without any Weyl group ambiguity. As one application of the correspondence, we identify the cubic anomaly tr R Q_I Q_J as an intersection product for dibaryon charges in large-N superconformal gauge theories. Examples can be given for all del Pezzo surfaces using three- and four-block exceptional collections. Markov-type equations enforce consistency among anomaly equations for three-block collections.Comment: 47 pages, 11 figures, corrected ref

A New Infinite Class of Quiver Gauge Theories

We construct a new infinite family of N=1 quiver gauge theories which can be Higgsed to the Y^{p,q} quiver gauge theories. The dual geometries are toric Calabi-Yau cones for which we give the toric data. We also discuss the action of Seiberg duality on these quivers, and explore the different Seiberg dual theories. We describe the relationship of these theories to five dimensional gauge theories on (p,q) 5-branes. Using the toric data, we specify some of the properties of the corresponding dual Sasaki-Einstein manifolds. These theories generically have algebraic R-charges which are not quadratic irrational numbers. The metrics for these manifolds still remain unknown.Comment: 29 pages, JHE